Pain, suffering and positive emotions in patients in vegetative state/unresponsive wakefulness syndrome (VS/uws) and minimally conscious states (MCS) pose clinical and ethical challenges. Clinically, we evaluate behavioural responses after painful stimulation and also emotionally-contingent behaviours (e.g., smiling). Using stimuli with emotional valence, neuroimaging and electrophysiology technologies can detect subclinical remnants of preserved capacities for pain which might influence decisions about treatment limitation. To date, no data exist as to how healthcare providers think about end-of-life options (e.g., withdrawal of artificial nutrition (...) and hydration) in the presence or absence of pain in non-communicative patients. Here, we aimed to better clarify this issue by re-analyzing previously published data on pain perception (Prog Brain Res 2009 177, 329–38) and end-of-life decisions (J Neurol 2010 258, 1058–65) in patients with disorders of consciousness. In a sample of 2259 European healthcare professionals we found that, for VS/uws more respondents agreed with treatment withdrawal when they considered that VS/uws patients did not feel pain (77%) as compared to those who thought VS/uws did feel pain (59%). This interaction was influenced by religiosity and professional background. For MCS, end-of-life attitudes were not influenced by opinions on pain perception. Within a contemporary ethical context we discuss (1) the evolving scientific understandings of pain perception and their relationship to existing clinical and ethical guidelines; (2) the discrepancies of attitudes within (and between) healthcare providers and their consequences for treatment approaches, and (3) the implicit but complex relationship between pain perception and attitudes toward life-sustaining treatments. (shrink)

This article explores the trend of increasing automation in law enforcement and criminal justice settings through three use cases: predictive policing, machine evidence and recidivism algorithms. The focus lies on artificial-intelligence-driven tools and technologies employed, whether at pre-investigation stages or within criminal proceedings, in order to decode human behaviour and facilitate decision-making as to whom to investigate, arrest, prosecute, and eventually punish. In this context, this article first underlines the existence of a persistent dilemma between the goal of increasing the (...) operational efficiency of police and judicial authorities and that of safeguarding fundamental rights of the affected individuals. Subsequently, it shifts the focus onto key principles of criminal procedure and the presumption of innocence in particular. Using Article 6 ECHR and the Directive (EU) 2016/343 as a starting point, it discusses challenges relating to the protective scope of presumption of innocence, the burden of proof rule and the _in dubio pro reo_ principle as core elements of it. Given the transformations law enforcement and criminal proceedings go through in the era of algorithms, big data and artificial intelligence, this article advocates the adoption of specific procedural safeguards that will uphold rule of law requirements, and particularly transparency, fairness and explainability. In doing so, it also takes into account EU legislative initiatives, including the reform of the EU data protection _acquis_, the E-evidence Proposal, and the Proposal for an EU AI Act. Additionally, it argues in favour of revisiting the protective scope of key fundamental rights, considering, _inter alia_, the new dimensions suspicion has acquired. (shrink)

Human-Computer Interaction (HCI) and games set a new domain in understanding people’s motivations in gaming, behavioral implications of game play, game adaptation to player preferences and needs for increased engaging experiences in the context of HCI serious games (HCI-SGs). When the latter relate with people’s health status, they can become a part of their daily life as assistive health status monitoring/enhancement systems. Co-designing HCI-SGs can be seen as a combination of art and science that involves a meticulous collaborative process. The (...) design elements in assistive HCI-SGs for Parkinson’s Disease (PD) patients, in particular, are explored in the present work. Within this context, the Game-Based Learning (GBL) design framework is adopted here and its main game-design parameters are explored for the Exergames, Dietarygames, Emotional games, Handwriting games, and Voice games design, drawn from the PD-related i-PROGNOSIS Personalized Game Suite (PGS) (www.i-prognosis.eu) holistic approach. Two main data sources were involved in the study. In particular, the first one includes qualitative data from semi-structured interviews, involving 10 PD patients and four clinicians in the co-creation process of the game design, whereas the second one relates with data from an online questionnaire addressed by 104 participants spanning the whole related spectrum, i.e., PD patients, physicians, software/game developers. Linear regression analysis was employed to identify an adapted GBL framework with the most significant game-design parameters, which efficiently predict the transferability of the PGS beneficial effect to real-life, addressing functional PD symptoms. The findings of this work can assist HCI-SG designers for designing PD-related HCI-SGs, as the most significant game-design factors were identified, in terms of adding value to the role of HCI-SGs in increasing PD patients’ quality of life, optimizing the interaction with personalized HCI-SGs and, hence, fostering a collaborative human-computer symbiosis. (shrink)

Hypocretin regulates brain reward function and cocaine consumption in rats. The hypocretinergic (Hcrt) system is implicated in energy homeostasis, feeding and sleep regulation. Hypocretinergic cell bodies are located in the lateral hypothalamus (LH) and project throughout the brain. The aim of the present studies was to investigate the role of the Hcrt system in regulating brain reward function and the reinforcing properties of cocaine in rats. Intracranial self-stimulation (ICSS) thresholds provide an accurate measure of brain reward function in rats. Here (...) we show that a single injection of Hcrt-1 (5 µg icv) induced persistent, long-lasting elevations in ICSS thresholds in drug-naïve rats. Indeed, Hrct-1 elevated ICSS thresholds for 36 h, with peak elevations between 6 and 12 hours after injection. Hrct-1-induced threshold elevations were attenuated by an antibody known to neutralize the binding of hcrt-1 to its receptors. Taken together, these observations suggest that Hrct-1 negatively regulates brain reward function in rats. Because Hrct-1 negatively regulates brain reward function, we hypothesized that it may attenuate the increased brain reward function usually observed after cocaine consumption, and thereby alter cocaine self-administration behavior. A daily injection of Hrct-1 (1 µg icv), for 4 consecutive days, slightly increased cocaine self-administration (0.25 mg/infusion) in rats. Overall, these data demonstrate that Hrct-1 negatively regulates brain reward function, and as such may indirectly alter cocaine self-administration. Given the well-established role of hypocretin neurons in regulating feeding behavior and sleep, we hypothesize that hypocretinergic regulation of brain reward function may provide a mechanism by which appropriate and competing behaviors (e.g. sleep or feeding) may be engaged to maintain energy homeostasis. (shrink)

A moving cultural biography of abolitionist martyr John Brown, by one of the most important African-American intellectuals of the twentieth century. In the history of slavery and its legacy, John Brown looms large as a hero whose deeds partly precipitated the Civil War. As Frederick Douglass wrote: "When John Brown stretched forth his arm... the clash of arms was at hand." DuBois's biography brings Brown stirringly to life and is a neglected classic.

Tutte le dottrine tradizionali, da quelle più arcaiche e "primitive" a quelle più evolute e articolate, hanno sempre affermato che l'uomo non è un essere solamente corporeo, sia pur dotato di ingegno e di intelligenza, ma è un essere dalla natura composita, formato da una parte materiale e da una o più componenti invisibili e "sottili" e che in lui risiede un principio immortale di origine divina o comunque soprannaturale. Secondo il modo di vedere tradizionale, l'uomo, per conoscere e realizzare (...) se stesso, deve pertanto prendere coscienza, in primo luogo ed essenzialmente, di questa sua natura di essere composito e immortale, e questa è una di quelle idee universali (per noi forse la più importante) che troviamo diffuse presso tutte le popolazioni del pianeta, anche se con sfumature diverse nelle varie tradizioni..."--Cover flap. (shrink)

Across a wide range of legal contexts, E. Thomas Sullivan and Richard S. Frase identify three basic ways that government measures and private remedies have been ...

The Congregation for the Doctrine of the Faith, under the prefecture of Joseph Ratzinger, published its instruction Donum vitae in 1987 to provide moral guidance on bioethical issues. Since 1987, many new ethical issues have arisen, especially in the areas of regenerative medicine (which includes stem cellresearch) and assisted reproduction. To address these the CDF, under the prefecture of William Levada, published the bioethical instruction Dignitas personae inDecember 2008. The present symposium includes reflections on the strengths and weaknesses of the (...) new document by six moral theologians noted for theirwork in bioethics: Christian Brugger, John Finnis, Luke Gormally, Christopher Kaczor, William E. May, and Peter F. Ryan, S.J. National Catholic Bioethics Quarterly 9.3 (Autumn 2009): 461–483. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 493 La Trinite Creatrice. By GILLES EMERY. Paris: Vrin, 1995. Pp. 590 (paper). It was only a question of when, not if, the late rejection of Thomism in Catholic circles would be followed by the next tum toward the thought of the Angelic Doctor. This movement is already underway, and on the European continent two groups of young Dominicans are playing prominent roles. In Toulouse, though he (...) only assumed its editorship in 1991, S.-T. Bonino already has made the venerable Revue thomiste indispensable reading again. Two recent thematic issues are especially noteworthy: "Autour d'Etienne Gilson" (94 [1994): 355-553) and "S. Thomas et l'onto-theologie" (95 [1995): 1-192). Bonino's own bulletins et recensions are erudite and lively, and he is very clear about the present situation: After the decline of the last decades, Thomism is searching for a new 6lan, a new look, and not without success:... the corpse of Thomism is stirring again. Though the new look is not yet complete, one feature is set: One common point unites all now approaching the works of St. Thomas, whatever their ultimate goals: the necessity to put Thomistic doctrine into serious historical perspective.... Historical-doctrinal study of St. Thomas is opening the possibility of an authentic revival of Thomism. (Revue thomiste 95 [1995]: 485-6) While Anglo-Americans approaching Aquinas from neoscholastic or analytic perspectives might not be so enthusiastic about history, Fr. Bonino is simply correct. For evidence, he turns to the historical work of the other group of Dominicans, at Fribourg. Chief among them is J.-P. Torrell, whose masterful 1993 biography, Initiation d saint Thomas d'Aquin, is now in English, and was accompanied by a Festschrift for the eminent professor of theologyOrdo sapientiae et amoris, ed. C.-J. de Oliveira. Not least among Torrell's contributions has been to direct the thesis of Gilles Emery-La Trinite creatrice. One paragraph of Emery's helpful general conclusion reveals three dominant themes in his important work: In virtue of the nexus mysteriorum, faith in the Trinity clarifies faith in the creative and saving activity of God, while the doctrine of creation in its turn clarifies our approach to the mystery of the Trinity. It is this mutual clarification and support among the articles of faith that we mean by speaking of the "function" of the theme of the creative Trinity. The unity of the Trinity in its works ad extra constitutes a fundamental rule of the trinitarian theology of our scholastics. But it does not exhaust their theological discourse on the subject of God as creator. To arrive at a balanced doctrine, trying to give all the aspects of the mystery their due, one must add to the rule of unity a second rule, which completes it: the procession of the divine persons is the origin of the procession of creatures. (519) Emery's primary theme is captured in the title-The Creative Trinity. Creation involves not only the one God as efficient cause bestowing existence 494 BOOK REVIEWS on a multitude of creatures (rule 1), but also the Trinitarian multiplicity within God as exemplar cause of the procession of creatures (rule 2). The neoscholastics ignored rule 2, separating creation (which was turned over to the philosophers) from Trinity (the exclusive domain of the theologians). This too neat division oflabor produced unhappy consequences: a doctrine ofcreation with no role for the Trinity, and a doctrine of the Trinity with no function in creation. What can be called Emery's Trinitarian theme is a corrective for such mistakes. To understand this side of creation rightly, Emery situates Aquinas's thought in relation to Albert and Bonaventure, on whom he heavily depends. This is his hi,storical theme. From the development of these two principal themes there gradually emerges a third, less overt, but in the long run of signal importance for the new look of Thomism-what might be called the integration theme, uniting reason and revelation in Aquinas's theology. To break through the crust that had built up around Aquinas's genuine doctrine of creation Emery turns to history. Limiting himself to the Scriptum super libros Sententiarum, he finds the Trinitarian... (shrink)

Part two of the proceedings of the fifth International Congress of Logic, Methodology and Philosophy of Science, London, Ontario, Canada, August 27 - September 2, 1975.

In this note I shall: discuss Vivas' definition of "naturalism" and his criticism of naturalistic theories; characterize a naturalistic theory which Vivas overlooks, and which, hence, invalidates his attempted refutation; suggest criticisms of Vivas' "axiological realism", with special attention to the central doctrine of the objectivity of values.

Academic freedom has become the enemy of the individual professors working in colleges and universities across the United States. Despite its historical (and maybe even essential) roots in the First Amendment, contemporary case law has consistently shown that professors, unlike most members of society, have no rights to free speech on their respective campuses. (Ironically, this is especially true on our State campuses.) Outlined is the dramatic change in the history of the courts from recognizing “academic freedom” as a construct (...) needed to protect professors from the status quo, to the abuse of “academic freedom” appropriated to protect the institution from “undesirable” professorial actions such as politically incorrect speech or research. Klein warns all those in the academy to become familiar with this pernicious 180-degree turn in the use of the “academic freedom” construct. (shrink)

Some data from earlier work concerning the evolutionary correlation of anthophilous insects, entomophilous plants, herbivorous animals, and natural soil groups are briefly summarized. Presumed successive evolution of plant and animal communities from the early Paleozoic era to the more recent formation of prairies, steppes and other grassland areas is described and pictured in Fig. 6. A definite correlation has been found among the coevolution of flowering plants, pollinating insects, ruminant animals and fertility grades of natural soil groups .Plants, insects, animals (...) and soil are interrelated in evolution as reciprocal selective and regulating factors in certain biotic and abiotic environments. This complex system can be better studied by application of the coenogenic concept and hologenic and syngenic methods.Various stages of the development of an agricultural environment in the prairie areas of the North American plains are briefly described and illustrated in Plates I–VII. A new radical change in the development by the introduction of so-called “Circle Farming” is pictured in Plates VIII–IX. This new irrigated farming system is not only profitable for the increasing of yields, but promises to some extent the restoration of a biologically balanced environment in an extensively cultivated agricultural landscape. (shrink)